Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC004
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-01 10:21
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 3x1/4 New patient (first test done 15.02.2022.)

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 30 individuals with a value less than 0.63 were subsequently diagnosed with PD. That is, 71.43% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.63 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 12, 'TN': 11, 'TP': 30, 'FP': 19}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 0, 'TN': 1, 'TP': 42, 'FP': 29}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 25, 'TN': 21, 'TP': 17, 'FP': 9}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 6, 'TP': 33, 'FP': 24}

Test Battery Details

Circle

numCircles 11
timePerCircleMean 6.45091
timePerCircleCoV 0.567537
timePerCircleSlope -0.117644
meanError 2.28164
tremorFreq 6.25
tremorRelPower 34.7985
tremorGyroAmpMean 0.0352361
tremorGyroAmpSlope -0.00700951
tremorGyroAmpCoV 0.285647
tremorCoordAmpMean 0.0703517
tremorCoordAmpSlope -0.00586842
tremorCoordAmpCoV 0.266827
tremorAccAmpMean 0.0909308
tremorAccAmpSlope -0.00356047
tremorAccAmpCoV 0.129029
tremorPcRelVar 0.693615
tremorPcX -0.606063
tremorPcY 0.795417

Circle Segment 1

Duration 8.52 s, Accuracy Estimate 2.973 (lower is better)

Circle Segment 2

Duration 16.6 s, Accuracy Estimate 4.282 (lower is better)

Circle Segment 3

Duration 7.56 s, Accuracy Estimate 1.383 (lower is better)

Circle Segment 4

Duration 5.72 s, Accuracy Estimate 1.915 (lower is better)

Circle Segment 5

Duration 5.88 s, Accuracy Estimate 1.765 (lower is better)

Circle Segment 6

Duration 4.92 s, Accuracy Estimate 1.873 (lower is better)

Circle Segment 7

Duration 4.12 s, Accuracy Estimate 2.071 (lower is better)

Circle Segment 8

Duration 4.56 s, Accuracy Estimate 2.151 (lower is better)

Circle Segment 9

Duration 4.56 s, Accuracy Estimate 1.71 (lower is better)

Circle Segment 10

Duration 4.0 s, Accuracy Estimate 2.556 (lower is better)

Circle Segment 11

Duration 4.52 s, Accuracy Estimate 2.42 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 16.22
timePerSpiralCoV 0.0787885
timePerSpiralSlope -0.0158278
meanError 1.87526
tremorFreq 6.73828
tremorRelPower 40.6817
tremorGyroAmpMean 0.0270525
tremorGyroAmpSlope -0.000308747
tremorGyroAmpCoV 0.381513
tremorCoordAmpMean 0.0757479
tremorCoordAmpSlope -0.000364827
tremorCoordAmpCoV 0.328618
tremorAccAmpMean 0.0589101
tremorAccAmpSlope -0.000380717
tremorAccAmpCoV 0.357738
tremorPcRelVar 0.698884
tremorPcX 0.623262
tremorPcY 0.782013

Spiral Segment 1

Duration 18.48 s, Accuracy Estimate 1.911 (lower is better)

Spiral Segment 2

Duration 17.44 s, Accuracy Estimate 1.746 (lower is better)

Spiral Segment 3

Duration 16.92 s, Accuracy Estimate 1.946 (lower is better)

Spiral Segment 4

Duration 15.16 s, Accuracy Estimate 1.729 (lower is better)

Spiral Segment 5

Duration 16.84 s, Accuracy Estimate 2.016 (lower is better)

Spiral Segment 6

Duration 15.24 s, Accuracy Estimate 1.967 (lower is better)

Spiral Segment 7

Duration 14.96 s, Accuracy Estimate 1.857 (lower is better)

Spiral Segment 8

Duration 15.6 s, Accuracy Estimate 1.853 (lower is better)

Spiral Segment 9

Duration 14.6 s, Accuracy Estimate 1.747 (lower is better)

Spiral Segment 10

Duration 16.96 s, Accuracy Estimate 1.981 (lower is better)

Elel

eDurationMean 0.512179
eDurationStd 0.119488
eDurationStdnorm 0.233293
eDurationMedian 0.485
eDurationQuartdelta 0.11125
eDurationQuartdeltanorm 0.229381
eDurationKurt 7.14711
eDurationTrenddiff -0.1
eDurationTrendratio 0.814815
eWidthMean 5.214
eWidthStd 1.48209
eWidthStdnorm 0.284251
eWidthMedian 5.148
eWidthQuartdelta 2.07675
eWidthQuartdeltanorm 0.403409
eWidthKurt 2.40518
eWidthTrenddiff -1.404
eWidthTrendratio 0.764706
eHeightMean 10.263
eHeightStd 1.64435
eHeightStdnorm 0.160222
eHeightMedian 9.945
eHeightQuartdelta 2.19375
eHeightQuartdeltanorm 0.220588
eHeightKurt 3.30539
eHeightTrenddiff -1.287
eHeightTrendratio 0.882979
eAspectMean 0.504492
eAspectStd 0.101241
eAspectStdnorm 0.200679
eAspectMedian 0.491803
eAspectQuartdelta 0.121686
eAspectQuartdeltanorm 0.247429
eAspectKurt 3.19787
eAspectTrenddiff -0.0584812
eAspectTrendratio 0.890503
eSlantMean 0.018875
eSlantStd 0.141547
eSlantStdnorm 7.49919
eSlantMedian 0.0212766
eSlantQuartdelta 0.200045
eSlantQuartdeltanorm 9.4021
eSlantKurt 2.70665
eSlantTrenddiff 0.00281979
eRtopMean 0.860817
eRtopStd 0.0891389
eRtopStdnorm 0.103552
eRtopMedian 0.891304
eRtopQuartdelta 0.110376
eRtopQuartdeltanorm 0.123836
eRtopKurt 4.15029
eRtopTrenddiff -0.0147541
eRbotMean 0.856041
eRbotStd 0.267133
eRbotStdnorm 0.312056
eRbotMedian 0.818182
eRbotQuartdelta 0.343414
eRbotQuartdeltanorm 0.419728
eRbotKurt 3.03998
eRbotTrenddiff 0.0512821
eRrightMean 0.943022
eRrightStd 0.0576294
eRrightStdnorm 0.0611114
eRrightMedian 0.951807
eRrightQuartdelta 0.0417366
eRrightQuartdeltanorm 0.0438498
eRrightKurt 10.8012
eRrightTrenddiff -0.00273823
eRleftMean 0.384231
eRleftStd 0.107774
eRleftStdnorm 0.280493
eRleftMedian 0.363636
eRleftQuartdelta 0.181315
eRleftQuartdeltanorm 0.498615
eRleftKurt 2.01327
eRleftTrenddiff 0.0238231
lDurationMean 0.662
lDurationStd 0.15483
lDurationStdnorm 0.233882
lDurationMedian 0.605
lDurationQuartdelta 0.16
lDurationQuartdeltanorm 0.264463
lDurationKurt 4.76045
lDurationTrenddiff -0.15
lDurationTrendratio 0.791667
lWidthMean 10.2525
lWidthStd 2.84165
lWidthStdnorm 0.277165
lWidthMedian 10.413
lWidthQuartdelta 4.29975
lWidthQuartdeltanorm 0.412921
lWidthKurt 2.92455
lWidthTrenddiff -0.936
lWidthTrendratio 0.910112
lHeightMean 22.4339
lHeightStd 2.39684
lHeightStdnorm 0.10684
lHeightMedian 22.347
lHeightQuartdelta 3.2175
lHeightQuartdeltanorm 0.143979
lHeightKurt 2.60134
lHeightTrenddiff 0.819
lHeightTrendratio 1.03704
lAspectMean 0.456254
lAspectStd 0.109083
lAspectStdnorm 0.239084
lAspectMedian 0.443182
lAspectQuartdelta 0.173598
lAspectQuartdeltanorm 0.391708
lAspectKurt 2.85694
lAspectTrenddiff -0.0754497
lAspectTrendratio 0.841639
lSlantMean 0.189826
lSlantStd 0.120777
lSlantStdnorm 0.636249
lSlantMedian 0.187879
lSlantQuartdelta 0.172866
lSlantQuartdeltanorm 0.920095
lSlantKurt 3.22617
lSlantTrenddiff -0.0174242
lRtopMean 0.913362
lRtopStd 0.0697624
lRtopStdnorm 0.0763798
lRtopMedian 0.938596
lRtopQuartdelta 0.0851804
lRtopQuartdeltanorm 0.090753
lRtopKurt 5.52569
lRtopTrenddiff 0.00109649
lRbotMean 0.539153
lRbotStd 0.21949
lRbotStdnorm 0.407101
lRbotMedian 0.489796
lRbotQuartdelta 0.244043
lRbotQuartdeltanorm 0.498255
lRbotKurt 14.3469
lRbotTrenddiff -0.0661388
lRrightMean 0.951238
lRrightStd 0.0332293
lRrightStdnorm 0.0349327
lRrightMedian 0.951872
lRrightQuartdelta 0.0381885
lRrightQuartdeltanorm 0.0401194
lRrightKurt 5.50671
lRrightTrenddiff 0.00263158
lRleftMean 0.240904
lRleftStd 0.0963381
lRleftStdnorm 0.399903
lRleftMedian 0.220264
lRleftQuartdelta 0.0809298
lRleftQuartdeltanorm 0.367421
lRleftKurt 6.78496
lRleftTrenddiff -0.0687395

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.887718
sumTouchScores 19.5298
meanMovementTime 0.83119
numTouches 22
undershootPercentage 4.54545
overshootPercentage 18.1818

FITTS Long Modified

meanTouchScore 0.944148
sumTouchScores 11.3298
meanMovementTime 1.66773
numTouches 12
undershootPercentage 0
overshootPercentage 25

ZigZag

numZigzags 5
timePerZigzagMean 25.784
timePerZigzagCoV 0.109178
timePerZigzagSlope -0.0497983
meanError 2.09
tremorFreq 6.64062
tremorRelPower 39.5201
tremorGyroAmpMean 0.039057
tremorGyroAmpSlope -0.00110901
tremorGyroAmpCoV 0.399106
tremorCoordAmpMean 0.0865807
tremorCoordAmpSlope -0.00101709
tremorCoordAmpCoV 0.342323
tremorAccAmpMean 0.0743378
tremorAccAmpSlope -0.00116525
tremorAccAmpCoV 0.349656
tremorPcRelVar 0.679317
tremorPcX -0.900536
tremorPcY 0.434781

ZigZag Segment 1

Duration 29.6 s, Accuracy Estimate 2.196 (lower is better)

ZigZag Segment 2

Duration 27.12 s, Accuracy Estimate 2.072 (lower is better)

ZigZag Segment 3

Duration 24.4 s, Accuracy Estimate 2.069 (lower is better)

ZigZag Segment 4

Duration 22.12 s, Accuracy Estimate 2.041 (lower is better)

ZigZag Segment 5

Duration 25.68 s, Accuracy Estimate 2.072 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 17.632
timePerZigzagCoV 0.41186
timePerZigzagSlope -0.232759
zigzagHeightMean 63.0765
zigzagHeightCoV 0.0444035
zigzagHeightSlope -0.00259708
meanError 0.0464447
tremorFreq 6.64062
tremorRelPower 34.9833
tremorGyroAmpMean 0.0451709
tremorGyroAmpSlope 0.00430924
tremorGyroAmpCoV 0.352227
tremorCoordAmpMean 0.0873779
tremorCoordAmpSlope 0.00748552
tremorCoordAmpCoV 0.329455
tremorAccAmpMean 0.0730537
tremorAccAmpSlope 0.00506758
tremorAccAmpCoV 0.34306
tremorPcRelVar 0.572177
tremorPcX 0.115351
tremorPcY 0.993325

ZigZag Offset Segment 1

Duration 29.92 s, Accuracy Estimate 0.079 (lower is better)

ZigZag Offset Segment 2

Duration 17.28 s, Accuracy Estimate 0.047 (lower is better)

ZigZag Offset Segment 3

Duration 16.36 s, Accuracy Estimate 0.023 (lower is better)

ZigZag Offset Segment 4

Duration 13.12 s, Accuracy Estimate 0.036 (lower is better)

ZigZag Offset Segment 5

Duration 11.48 s, Accuracy Estimate 0.047 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.8}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.63}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.6049941328895267}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8506036384684621}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.706231129889266}